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18F-S2P
- Development stage
- Unknown
- Lead developer
- First Affiliated Hospital, Zhejiang University School of Medicine
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
18F-S2P is a fluorine-18 labeled peptide-based positron emission tomography (PET) radiotracer designed for the non-invasive imaging of atherosclerotic plaques. It specifically targets Stabilin-2 (STAB2), a scavenger receptor that is highly upregulated on macrophages within inflamed atherosclerotic lesions. By binding to STAB2, 18F-S2P enables the visualization and quantification of vascular inflammation and plaque burden, offering a highly sensitive diagnostic tool for large-artery atherosclerosis. The tracer is being developed by the First Affiliated Hospital of Zhejiang University School of Medicine.
- Other names
- 18F-S2P peptide18F-labeled S2P18F-labeled S2P peptide[18F]S2Pfluorine-18 S2Pfluorine18 S2Pfluorine 18 S2P
02
Targets
STAB2 (Stabilin-2)
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