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18F-siPSMA-14
- Development stage
- Unknown
- Lead developer
- Ulm University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
18F-siPSMA-14 is a silicon-based, fluorine-18-labeled radiopharmaceutical tracer targeting prostate-specific membrane antigen (PSMA). It was developed by the Technical University of Munich in collaboration with Ulm University and Scintomics. The tracer utilizes a silicon-fluoride acceptor (SiFA) moiety, which allows for a simplified, fast, and scalable one-step isotopic exchange (18F-for-19F) radiolabeling process at room temperature without the need for complex purification or high-temperature heating. 18F-siPSMA-14 is designed for positron emission tomography (PET) imaging of prostate cancer, enabling high-contrast visualization of primary and metastatic lesions without requiring forced diuresis.
- Other names
- [18F]F-siPSMA-14[18F]siPSMA-14[F-18]siPSMA-14F-18-siPSMA-14F18-siPSMA-14F 18-siPSMA-14
02
Targets
PSMA (Prostate-specific membrane antigen)
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