18F-TATE

18F-TATE is a radiolabeled somatostatin analog developed for the diagnostic imaging of neuroendocrine tumors (NETs) using positron emission tomography (PET). It typically comprises the somatostatin receptor-targeting peptide [Tyr3]octreotate (TATE) conjugated to a chelating agent like NOTA, which is then labeled with the radioisotope fluorine-18, often utilizing the aluminum fluoride ([Al18F]2+) complexation method. The tracer specifically targets somatostatin receptors (primarily SSTR2), which are highly expressed on the surface of NET cells. 18F-TATE is designed to overcome the logistical limitations of 68Ga-labeled tracers, such as 68Ga-DOTATATE, by leveraging the longer half-life (110 minutes) and superior imaging characteristics of fluorine-18, enabling centralized production and potentially higher-resolution imaging.

Other names

[18F]AlF-NOTA-octreotate18F-AlF-NOTA-DOTATATE18F-AlF-NOTA-TATE18F-labeled somatostatin analog