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18F-TFAHA
- Development stage
- Preclinical
- Lead developer
- Wayne State University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
18F-TFAHA (6-(tri-fluoroacetamido)-1-hexanoicanilide) is a radiolabeled small molecule PET imaging tracer designed to visualize the expression and activity of Class IIa histone deacetylases (HDACs), specifically HDAC4 and HDAC5. Developed by researchers at Wayne State University, the molecule acts as a substrate that is enzymatically cleaved specifically by HDAC class IIa enzymes. In preclinical models of human glioma, 18F-TFAHA PET/CT/MRI imaging has demonstrated the ability to quantitatively map epigenetic regulation and monitor pharmacodynamic responses to HDAC inhibitors like vorinostat. Its primary application is the non-invasive assessment of HDAC activity in brain tumors and other cancers where epigenetic dysregulation plays a role in pathogenesis.
- Other names
- [18F]TFAHA
02
Targets
HDAC4HDAC5 (Histone deacetylase 5)HDAC7HDAC9
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