18F-TMP195

18F-TMP195 is a fluorine-18 labeled radiopharmaceutical and positron emission tomography (PET) imaging tracer designed to target class IIa histone deacetylases (HDACs), specifically HDAC4, HDAC5, HDAC7, and HDAC9. It is a radiolabeled analog of TMP195, a potent and selective class IIa HDAC inhibitor that utilizes a trifluoromethyloxadiazole (TFMO) moiety for high specificity. Developed primarily for the molecular imaging of pancreatic ductal adenocarcinoma (PDAC), 18F-TMP195 binds to the active site of endogenous class IIa HDACs, which are frequently overexpressed in various human cancers. This tracer serves as a non-invasive biomarker to visualize HDAC expression patterns in vivo, potentially aiding in the diagnosis of pancreatic cancer and the prediction of therapeutic response to class-specific HDAC inhibitors.

Other names

[18F]TMP19518F-labeled TMP19518F-TFMO-TMP195