192 IgG-saporin

192 IgG-saporin is a **targeted immunotoxin** composed of the mouse monoclonal antibody **192 IgG**, which specifically binds to the **p75 neurotrophin receptor (NGFR, low-affinity nerve growth factor receptor)**, conjugated to **saporin**, a ribosome-inactivating protein. The antibody component confers selectivity for cholinergic neurons—primarily in the basal forebrain—while the saporin payload induces cell death by irreversibly inactivating ribosomes. This immunotoxin is widely used in neuroscience research to selectively ablate cholinergic neurons in animal models, especially to create models of disorders featuring cholinergic hypofunction, such as **Alzheimer’s disease**, via intracerebroventricular (i.c.v.) injection. The drug’s action leads to memory deficits and other behavioral changes, primarily through the loss of cholinergic input to the hippocampus and cortex, with secondary effects on microglia and non-cholinergic systems[1][2][3][4][5][6].

Brand names

192 IgG-saporin

Other names

192 IgG-saporin192-IgG-SAPIg-saporin192 IgG-SAPanti-p75-SAPanti-p-75-SAPanti-p 75-SAPanti-neuronal immunotoxin