1% metformin gel

1% metformin gel is a locally-delivered, biodegradable, controlled-release formulation developed by researchers at the Government Dental College and Research Institute in Bangalore, India. While metformin is traditionally an oral biguanide used for type 2 diabetes, this specific formulation is designed for subgingival application as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis and intrabony periodontal defects. The drug exerts its therapeutic effect by promoting osteoblast proliferation and differentiation, leading to bone-sparing effects and the regeneration of alveolar bone within periodontal pockets. Clinical trials have demonstrated significant improvements in clinical parameters such as probing depth reduction, clinical attachment level gain, and bone defect fill compared to scaling and root planing alone.

Other names

1% MF gellocally delivered metformin gelmetformin gel