2,3-butanedione monoxime

2,3-Butanedione monoxime (BDM), also known as diacetylmonoxime, is a small molecule organic compound widely used as a research tool and pharmacological agent. It is well-characterized as a low-affinity, non-competitive inhibitor of skeletal muscle myosin-II, which effectively blocks skeletal and cardiac muscle contraction. Consequently, it is frequently employed in physiological and electrophysiological studies as an electromechanical uncoupler to eliminate motion artifacts in optical recordings. Beyond its effects on myosin, BDM exhibits a broad range of off-target activities, including the inhibition of L-type calcium channels and voltage-gated potassium channels (such as Kv2.1), as well as acting as a chemical phosphatase and a reactivator of phosphorylated acetylcholinesterase in organophosphate poisoning models. In parasitology research, BDM is also utilized as an endocytosis inhibitor to study pathways such as the haem detoxification pathway in *Plasmodium falciparum*.

Other names

2,3-butanedione 2-monoxime2,3-butanedione monoximeBDMbiacetyl monoximebutanedione-2,3 monoximediacetyl monoximediacetylmonoxime