2-(2-benzofuranyl)-2-imidazoline

**2-BFI** (chemical name: 2-(2-benzofuranyl)-2-imidazoline) is a small molecule that acts as a high-affinity and selective agonist at the imidazoline I₂ receptor (I₂R). It has been widely used in research to study the function of I₂ receptors and their role in neuropharmacology. Preclinical studies indicate that it potentiates morphine antinociception and produces specific behavioral effects in animal models with nigrostriatal lesions. Additionally, it has shown neuroprotective effects in stroke models by modulating mTOR signaling and reducing neuroinflammation. Its primary use is as a research tool rather than for clinical therapy[1][3][6].

Other names

2-BFI hydrochlorideRX 801077 hydrochlorideRX801077 hydrochlorideRX-801077 hydrochloride2-(benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride2-(Benzofuran-2-yl)-2-imidazoline hydrochloride