2-(2-bromophenylamino)-5-(3-fluorophenyl)-1,3,4-thiadiazole

2-(2-bromophenylamino)-5-(3-fluorophenyl)-1,3,4-thiadiazole (Compound B3) is a synthetic small molecule and a nonsteroidal aromatase inhibitor. It features a 1,3,4-thiadiazole scaffold substituted with 2-bromophenylamino and 3-fluorophenyl groups. In preclinical studies, the compound demonstrated selective cytotoxicity against estrogen-dependent breast cancer cell lines (MCF-7) compared to estrogen-independent lines (MDA-MB-231), suggesting its potential for treating hormone-responsive malignancies. Molecular modeling and dynamics simulations indicate that it binds to the active site of the aromatase enzyme in a manner similar to native inhibitors, effectively blocking the biosynthesis of estrogen.

Other names

N-(2-bromophenyl)-5-(3-fluorophenyl)-1,3,4-thiadiazol-2-amineCompound B3