2-(2-methylphenyl)-1H-indole-6-carboximidamide

A synthetic small molecule belonging to the class of organic compounds known as 2-phenylindoles. It features an indole core substituted at the 2-position with a methyl-substituted phenyl group and a carboximidamide functional group at the 6-position[1][5][6]. This compound has been studied primarily in experimental settings for its antiproliferative (anticancer) and neuroprotective properties. Mechanistically, it induces apoptosis in cancer cells via caspase activation and modulates apoptotic markers such as Cytochrome C and Bcl-2 family proteins. It also inhibits kinases like EGFR and CDK2, contributing to its anticancer effects[5]. Preliminary research suggests potential applications in neurodegenerative diseases such as Alzheimer's disease by targeting neuronal apoptosis pathways[5][8].

Other names

2-(2-methylphenyl)-1H-indole-6-carboximidamide2-(2-Methylphenyl)-1H-indol-6-carboximidamid1H-Indole-6-carboximidamide, 2-(4-carbamimidoylphenyl)-2-(4-carbamimidoylphenyl)-1H-indole-6-carboximidamide