Drug intelligence / Profile preview

2-acetyl-thiamine diphosphate

Development stage
Unknown
Modality
Small Molecules
01

Overview

This compound is a synthetic derivative of thiamine (vitamin B1), specifically the acetylated form of thiamine diphosphate (also known as thiamine pyrophosphate). Thiamine diphosphate is an essential coenzyme for several enzymes involved in carbohydrate metabolism and energy production. The acetyl modification may alter its biochemical properties or stability but retains the core function as a cofactor. Its mechanism of action involves acting as a coenzyme for decarboxylation reactions in metabolic pathways such as the citric acid cycle and pentose phosphate pathway. This compound is primarily used in research settings to study enzyme mechanisms and vitamin B1 metabolism[1][2][9].

Other names
2-Acetyl-3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-(4,6,6-Trihydroxy-3,5-Dioxa-4,6-Diphosphahex-1-Yl)Thiazolium Inner Salt P,P'-Dioxide2-acetyl-thiamine diphosphate2-acetylthiamine pyrophosphate2-acetylthiamine diphosphate2-acetylthiamin diphosphate2-acetylthiamin pyrophosphate
02

Targets

PDHA1 (Pyruvate dehydrogenase E1 component subunit alpha 1)

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