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2-aminoacetophenone
- Development stage
- Preclinical
- Lead developer
- Krufren Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
2-aminoacetophenone is a small molecule drug candidate currently in the preclinical pipeline of Krufren Pharma. It is being investigated for the treatment of undisclosed rare diseases, likely within the realm of metabolic or genetic disorders, which is the primary focus of the developer. While 2-aminoacetophenone is naturally occurring as a metabolite of the kynurenine pathway and is known as a volatile signaling molecule produced by *Pseudomonas aeruginosa*, its specific therapeutic mechanism of action and biological target in Krufren's development program have not been publicly disclosed. Krufren Pharma, a Spanish biotechnology company specializing in orphan drugs, positions this compound as an early-stage asset in its rare disease portfolio.
- Other names
- o-aminoacetophenone1-(2-aminophenyl)ethanoneortho-aminoacetophenone2-acetylaniline
02
Targets
Autophagy (Autophagy machinery (ATG family))
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