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2-azido-2-deoxy-D-glucose
- Development stage
- Preclinical
- Lead developer
- PACT & Health
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
2-azido-2-deoxy-D-glucose (2-AZ-2-DG) is an azido-modified glucose analog being investigated as a radiosensitizer and chemotherapeutic agent, particularly for the treatment of pancreatic ductal adenocarcinoma (PDAC). In the context of the I-RaGAZ platform, it is used in combination with targeted gold nanoparticles (T-GNPs) and X-ray radiation. The mechanism involves the production of aminyl radicals (RNH•) triggered by Auger electrons from the gold nanoparticles, which leads to DNA damage (strand breaks and crosslinks) and subsequent apoptosis in cancer cells. This approach aims to enhance tumor cell death while minimizing toxicity to surrounding normal tissues.
- Other names
- 2-azido-2-deoxyglucose
02
Targets
OGT (UDP-N-acetylglucosamine—peptide N-acetylglucosaminyltransferase)
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