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2-DeNT
- Development stage
- Phase 1
- Lead developer
- Texas A&M University
- Modality
- Small Molecules
- Administration
- Buccal, Topical
01
Overview
**2-DeNT** is a compounded mucoadhesive oral topical powder developed at Texas A&M University for treatment of minor recurrent aphthous stomatitis. It is a fixed-dose multi-active formulation containing dexamethasone, diphenhydramine, tetracycline, metronidazole, and nystatin; zinc oxide and karaya gum support powder retention and formulation properties. The formulation was evaluated in a randomized, blinded, placebo-controlled crossover Early Phase 1 study in patients with minor recurrent aphthous ulcers, with twice-daily application directly to oral lesions until resolution.
- Brand names
- 2-DeNT
- Other names
- 2-DeNT mucoadhesive powder2-DeNT oral topical powder2-DeNT powder
02
Targets
HRH1 (Histamine H1 Receptor)Bacterial RibosomeGR (Glucocorticoid receptor)DNAErgosterol
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