2-deoxy-2,3-dehydro-N-acetylneuraminic acid

**2-deoxy-2,3-dehydro-N-acetylneuraminic acid** is a synthetic small molecule derivative of N-acetylneuraminic acid (sialic acid) in which the hydroxy group at C‑2 is removed and the molecule is reduced across the 2,3-bond. It acts as a potent inhibitor of neuraminidases (sialidases) from viral (including influenza), bacterial, and mammalian sources by binding to their catalytic site as a transition state analog. This compound has been widely used in biochemical research to study sialidase function and glycoprotein interactions. It also serves as a lead structure for drug design targeting neuraminidase activity and has been explored for potential use in vaccine development and diagnostics[1][4][5][9].

Other names

deoxysialic aciddeoxy-N-acetylneuraminic acidN-acetylneuraminic acid, DANA2,3-dehydro-2-deoxy-N-acetylneuraminic acid2,3-didehydro-2-deoxy-N-acetylneuraminic acid5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid