2-deoxy-2-fluoro-β-D-mannose

**Description:** 2-deoxy-2-fluoro-beta-D-mannose is a synthetic monosaccharide derivative of mannose in which the hydroxyl group at the C‑2 position is replaced by a fluorine atom. It belongs to the class of hexoses and is structurally related to beta-D-mannopyranose[1][2][3]. This compound is primarily used as a research tool in glycobiology and carbohydrate metabolism studies. Its unique fluorine substitution makes it valuable for investigating glycan structure-function relationships and for use as a building block in drug discovery and glycomimetics[5]. Derivatives such as radiolabeled forms (e.g., ^18F-FDM) are being explored for diagnostic imaging applications like PET tumor imaging due to their altered metabolic properties compared to natural sugars[8]. The mechanism of action depends on its application; generally, it acts as an analog or probe rather than exerting direct pharmacological effects.

Other names

2-Fluoro-2-deoxy-D-mannose(2S,3S,4R,5R)-2-Fluoro-3,4,5,6-tetrahydroxyhexanal