2-deoxy-2-fluoro-alpha-D-mannosyl fluoride

**Description:** 2-deoxy-2-fluoro-alpha-D-mannosyl fluoride is a synthetic fluorinated sugar analog of mannose. It is classified as a small molecule and has the molecular formula C6H10F2O4. This compound is primarily used in biochemical research as an inhibitor or substrate analog for glycosidases and glycosyltransferases due to its structural similarity to natural mannose but with enhanced stability from the fluorine substitution. The presence of both a deoxy and fluoro group at the C‑2 position makes it resistant to enzymatic hydrolysis compared to native sugars. Its mechanism of action involves acting as a competitive inhibitor or mechanism-based inactivator for enzymes that process mannose-containing substrates[1][3][7]. There are no approved therapeutic indications; it is considered experimental.

Other names

2-DEOXY-2-FLUORO-ALPHA-D-MANNOSYL FLUORIDE(2R,3S,4S,5S)-5,6-difluoro-2-(hydroxymethyl)oxane-3,4-diolMan1F2FMan-1F2FMan 1F2F1,2-dideoxy-1,2-difluoro-D-manno-hexopyranose2-Deoxy-2-fluoro-D-mannopyranosyl fluoride