2-deoxy-D-galactose

2-deoxy-D-galactose is a deoxy sugar derivative and glucose/galactose analog that acts as an inhibitor of terminal fucosylation. Upon cellular uptake, it is metabolized via the Leloir pathway to uridine diphosphate (UDP)-2-deoxy-galactose, which competes with UDP-galactose for incorporation into glycan chains, thereby preventing the formation of Fucα(1,2)-Gal linkages. This inhibition of terminal fucosylation has been shown to reduce the shedding of terminally fucosylated glycans, decrease bacterial burden, and resolve neutrophilic inflammation in preclinical models of pneumococcal pneumonia. It has also been investigated in preclinical models of rheumatoid arthritis, hepatocellular carcinoma, renal fibrosis, and dry eye disease, as well as in cognitive studies where it induces reversible amnesia by disrupting glycoprotein fucosylation required for memory consolidation.

Other names

2-D-gal2-Deoxy-β-D-lyxo-hexose2-deoxy-D-galactopyranose2-deoxy-D-lyxo-hexose2-deoxy-galactose2-deoxygalactose2DGal2d-GalD-2-desoxygalactoseD2-desoxygalactoseD 2-desoxygalactosedeoxygalactose