2-fluoroadenine

**2-fluoroadenine** is a fluorinated adenine antimetabolite and purine nucleoside analog. It is cytotoxic and has been studied mainly as a research tool for cancer and gene therapy applications. It acts by interfering with nucleic acid synthesis, leading to inhibition of cell growth and induction of cell death. In research, it has been used to select cells or organisms deficient in adenine phosphoribosyltransferase (APT) by exploiting its toxicity to wild-type cells. It can be used in the synthesis of heat shock protein 90 (Hsp90) inhibitors with anticancer activity, acts broadly as an antineoplastic agent, and has also been investigated for suicide gene therapy in human malignancy. Its cytotoxicity is notable in human leukemia cells, with an IC50 of 0.15 µM[1][2][7].

Other names

2-fluoro-9H-purin-6-amine2-fluoro-7H-purin-6-amine2-faduoroadenine2-fluoro-adenin2-FLUOROADENINE2-Fluoro-6-aminopurine2-Fluoro-1H-purin-6-amine9H-Adenine, 2-fluoro-Adenine, 2-fluoro-(VAN)2-fluorohydropurine-6-ylamineSCHEMBL8850SCHEMBL-8850SCHEMBL 8850SCHEMBL8851SCHEMBL-8851SCHEMBL 8851