2-fluoroadenosine

2-Fluoroadenosine is a synthetic purine nucleoside analogue in which the adenosine molecule is modified by the substitution of a fluorine atom at the 2-position of the purine ring. It was originally developed at Southern Research Institute in 1957 as a potential anticancer agent. Unlike natural adenosine, it is not deaminated by adenosine deaminase and can be metabolized to its triphosphate form within cells. This compound acts as an inhibitor of lymphocyte-mediated cytolysis and has demonstrated cytotoxic effects on various cell lines in vitro. Its mechanism involves interference with nucleic acid synthesis and cellular metabolism due to its incorporation into RNA or DNA or inhibition of key biosynthetic enzymes. While it has been studied for antitumor and antiviral properties, including use as an intermediate for other drugs like fludarabine, there are no approved clinical indications for this compound itself[1][3][6].

Other names

2-(6-amino-2-fluoro-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol6-amino-2-fluoro-9-beta-D-ribofuranosylpurineAdenosine, 2-fluoro-2-fasnsc30605nsc-30605nsc 30605