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2-methyldihydrexidine
- Development stage
- Preclinical
- Lead developer
- Purdue University
- Modality
- Small Molecules
- Administration
- Injection
01
Overview
2-methyldihydrexidine is a selective, high-affinity full agonist at the dopamine D1 and D5 receptors. It is a derivative of dihydrexidine, which was the first non-catechol high-affinity full D1 agonist. Developed primarily as a research tool to investigate the dopaminergic system's role in cognitive functions, it has been studied for its potential in treating symptoms of attention-deficit/hyperactivity disorder (ADHD) and other cognitive impairments. Research indicates that 2-methyldihydrexidine can improve temporal order memory and spatial working memory in rodent models, particularly when co-administered with α2A-adrenergic agonists like guanfacine, suggesting a synergistic relationship between D1 and α2A receptor activation in the prefrontal cortex.
- Other names
- 2-methyl-dihydrexidine2-methyl-DHX
02
Targets
DRD1 (Dopamine D1 Receptor)DRD5 (Dopamine D5 Receptor)DRD2 (Dopamine D2 Receptor)
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