2-O-hexyldiglycerol

2-O-hexyldiglycerol is a short-chain alkylglycerol (AG) that acts as a transient and reversible blood-brain barrier (BBB) opening agent. It is primarily utilized as a drug delivery adjuvant to facilitate the penetration of therapeutic compounds, ranging from small molecules like methotrexate to large proteins such as globulins and antibodies, into the brain parenchyma. The mechanism of action involves increasing paracellular permeability by inducing the redistribution of tight junction-associated proteins, including claudin-5 and β-catenin, and potentially modulating the endothelial cytoskeleton. Research indicates that its effects are short-lived and do not permanently disrupt the complexity of tight junction strands, making it a promising tool for overcoming the BBB in the treatment of brain tumors and other central nervous system disorders.

Other names

2-O-hexyl-diglycerol2-hexyl-diglycerol