2-octyl cyanoacrylate (Ethicon)

Dermabond Advanced is a topical skin adhesive composed of a 2-octyl cyanoacrylate monomer, developed and marketed by Ethicon, a subsidiary of Johnson & Johnson. It is indicated for the topical closure of easily approximated skin edges from surgical incisions, including punctures from minimally invasive surgery, and simple, thoroughly cleansed, trauma-induced lacerations. Upon contact with moisture on the skin surface, the liquid monomer polymerizes into a strong, flexible film that holds the wound edges together. This film also acts as a microbial barrier with 99% protection in vitro for 72 hours against organisms commonly responsible for surgical site infections. The "Advanced" formulation is specifically designed for a single-layer application, providing a balance of strength and flexibility while improving drying time and ease of use for clinicians compared to multi-layer predecessors.

Brand names

Dermabond AdvancedDermabond

Other names

2-octyl cyanoacrylate topical skin adhesiveoctafonium chloridecyanoacrylate skin adhesive