Drug intelligence / Profile preview

2007RD01 + saw palmetto lipidic extract

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

2007RD01 + saw palmetto lipidic extract is a **combination dietary supplement** investigated for the treatment of **benign prostatic hyperplasia (BPH)**. 2007RD01 is described as a "natural extract" (specific identity not disclosed in the available sources), while saw palmetto lipidic extract (Serenoa repens) is an extract from the berry of the American dwarf palm, rich in fatty acids and phytosterols. The combination is being researched to determine if it is more effective than saw palmetto alone in improving urinary symptoms in BPH patients. Saw palmetto extract is theorized to work primarily via **inhibition of 5-alpha-reductase** (decreasing conversion of testosterone to dihydrotestosterone), **antagonism at alpha-1 adrenoceptors, muscarinic cholinoceptors, and other receptors in the lower urinary tract**, and **anti-inflammatory activity**. The extract may also inhibit cyclooxygenase and lipoxygenase pathways, providing additional anti-inflammatory and anti-androgenic effects[2][6][5].

02

Targets

ADRA1A (α1A)LTCC (Voltage-gated calcium channel (L-type))SRD5A (Steroid 5-alpha-reductase)mAChR (Muscarinic acetylcholine receptors)

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