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225Ac-PSMA-VG-01
- Development stage
- Preclinical
- Lead developer
- VitsGen Therapeutics
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Alpha Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
225Ac-PSMA-VG-01 is a preclinical-stage radionuclide drug conjugate (RDC) developed by VitsGen Therapeutics for the treatment of prostate cancer. The therapeutic agent targets prostate-specific membrane antigen (PSMA), a protein highly expressed on the surface of prostate cancer cells. It utilizes the alpha-emitting radioisotope Actinium-225 (225Ac) to deliver high-energy radiation directly to tumor cells, inducing double-strand DNA breaks and cell death while sparing adjacent healthy tissue. The program is currently in the preclinical phase, with an Investigational New Drug (IND) filing targeted for late 2024 and clinical trials expected to commence in mid-2025.
- Other names
- Actinium-225 PSMA-VG-01Actinium225 PSMA-VG-01Actinium 225 PSMA-VG-01
02
Targets
PSMA (Prostate-specific membrane antigen)
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