24-Homo-1,25-dihydroxyvitamin D3

24-Homo-1,25-dihydroxyvitamin D3 is a synthetic analogue of vitamin D. It is structurally related to calcitriol (the active form of vitamin D), but with a modification at the C24 position ("homo" indicates an additional methylene group). This compound acts as a vitamin D receptor agonist and is being investigated for its potential biological activities similar to those of natural vitamin D metabolites. Its primary mechanism involves binding to and activating the vitamin D receptor (VDR), thereby modulating gene expression involved in calcium and phosphate homeostasis as well as cell differentiation. It remains experimental and has not been approved for clinical use[1][2][3].

Other names

24-homo-calcitriol24-homo calcitriolcalcitriol impurities D(5Z,7E)-(1S,3R)-24a-homo-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol1alpha,25-dihydroxy-24a-homovitamin D31alpha,25-dihydroxy–24a-homocholecalciferol