26-succinylbryostatin 1

**26-succinylbryostatin 1** is a synthetic derivative of bryostatin 1, a macrocyclic lactone originally isolated from the marine bryozoan Bugula neritina. The addition of a succinyl group at position 26 results in a compound that is approximately 100-fold more water soluble than the parent bryostatin 1, facilitating alternative formulations for clinical use[1]. Like bryostatin 1, 26-succinylbryostatin 1 is a **modulator of protein kinase C (PKC)**, able to activate PKC in vitro and to stimulate AP-1-driven transcription and c-Jun phosphorylation in leukemic cells, indicating retained activity at some PKC-dependent pathways[1]. However, compared to bryostatin 1, it shows reduced potency for PKC activation and fails to induce PKC translocation, does not aggregate human platelets, and does not inhibit melanoma growth in mouse models at doses equivalent to bryostatin 1[1]. The compound is primarily of interest as a more water-soluble analog for research and potential drug development targeting PKC pathways, especially in oncology and cell differentiation studies.

Other names

triethanolamine salt of 26-succinylbryostatin 1