Drug intelligence / Profile preview

2C-B prodrug

Development stage
Preclinical
Lead developer
Terran Biosciences
Modality
Small Molecules
Administration
Oral
01

Overview

2C-B prodrug is a small molecule therapeutic candidate being developed by Terran Biosciences for the treatment of various neuropsychiatric disorders. The compound is designed as a prodrug of 2C-B (4-bromo-2,5-dimethoxyphenethylamine), a psychedelic phenethylamine that primarily acts as a partial agonist at the serotonin 5-HT2A receptor. By utilizing a prodrug approach, Terran aims to optimize the pharmacokinetic profile, potentially improving the oral bioavailability and therapeutic window of 2C-B. The program is part of Terran's broader pipeline of psychedelic-based therapies targeting mental health conditions.

Other names
2C-B prodrug
02

Targets

HTR2C (5-hydroxytryptamine 2C receptor)HTR2A (Serotonin receptor 5-HT2A)HTR1B (5-Hydroxytryptamine Receptor 1B)SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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