Drug intelligence / Profile preview

2K1

Development stage
Unknown
Modality
Small Molecules
01

Overview

2K1 is a specialized dietary supplement formulation containing a combination of two essential forms of Vitamin K: Vitamin K1 (phytonadione) and Vitamin K2 (specifically the menaquinone-4 or MK-4 isoform). Developed and manufactured by Bio-Tech Pharmacal, this product is designed to support bone density and cardiovascular health by leveraging the synergistic effects of different Vitamin K vitamers. Vitamin K1 is primarily known for its role in the hepatic synthesis of blood coagulation factors, while Vitamin K2 (MK-4) plays a critical role in extra-hepatic tissues, particularly in the regulation of calcium metabolism. By activating osteocalcin in bone and matrix Gla protein (MGP) in the vasculature, the components of 2K1 help direct calcium into the bone matrix and prevent its deposition in arterial walls, thereby supporting skeletal integrity and arterial flexibility.

Brand names
2K1
Other names
Vitamin K1 + Vitamin K2Phytonadione + Menaquinone-4
02

Targets

MGP (Matrix Gla protein)GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)

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