2QR-complex

The 2QR-complex (pronounced "to-cure") is a patented plant-based ingredient used in various healthcare products, particularly for treating microbial imbalances on skin and mucosa. It works by forming a physical barrier that prevents harmful microbes from adhering to human tissues, while allowing beneficial bacteria to flourish. ## Composition and Origin The 2QR-complex consists of large negatively charged multi-branched polymers derived from aloe vera gel (specifically Aloe barbadensis leaf polysaccharides)[1][2]. It was discovered and patented by BioClin together with the VU University in Amsterdam in 1998[5]. ## Mechanism of Action The 2QR-complex functions through a unique barrier mechanism: - It forms a protective viscous layer on tissues that shields epithelial cells from contact with pathogenic micro-organisms[6] - The complex binds with the adhesion system on the cell surface of pathogenic micro-organisms, preventing them from attaching to skin or mucosa[5] - By blocking harmful bacteria from binding to the substrate, beneficial bacteria can flourish through competitive exclusion[5] - Unlike antibiotics or antimicrobial agents, it does not kill microbes but renders them harmless by preventing their adhesion[5][6] ## Clinical Applications The 2QR-complex is used in various healthcare products for: 1. **Vaginal Health**: Products like Multi-Gyn ActiGel and Multi-Gyn FloraPlus contain 2QR-complex to treat vaginal discomforts by restoring the natural balance of vaginal flora[2][8] 2. **Oral Health**: Products have been developed to address oral cavity issues by correcting disturbed oral flora[5] 3. **Skin Conditions**: Used for treating and preventing microbial complaints affecting the skin[1] ## Benefits and Safety Profile The 2QR-complex offers several advantages over traditional antimicrobial treatments: - It is natural and plant-based with no known side effects[2][6] - Unlike disinfectants like chlorhexidine, it does not kill beneficial bacteria or disrupt the microbiota[5] - It does not provoke microbial resistance[5][6] - It is non-toxic to human cells and does not impair the healing process[5] - In vitro testing has shown that it blocks more than 99% of bacteria, demonstrating clear barrier function[6] The 2QR-complex represents an innovative approach to treating microbial imbalances by working with the body's natural defenses rather than through chemical or pharmacological action.

Brand names

Multi-Gyn ActiGelMulti-Gyn FloraPlus

Other names

Galactoarabinan Polyglucuronic Acid Crosspolymer