2T-P

**2T-P** is an experimental lipophilic phospholipid-tail conjugate of podophyllotoxin developed as a membrane-incorporating prodrug for ultrasound-triggered local drug delivery. The molecule was designed to improve incorporation and stability within liposomal, microbubble, and nanodroplet lipid membranes relative to unconjugated podophyllotoxin. In HeLa cervical-cancer cells, 2T-P showed substantially reduced cytotoxic potency relative to the related 2T-N construct, with an approximately 4 µM IC50; the authors attributed this reduction to steric hindrance from the phospholipid conjugation. It has only been described in preclinical in-vitro delivery studies and is not an approved medicine. ([ntno.org](https://www.ntno.org/v04p0040.pdf?v=1596498165))

Other names

2T-P