3,4-dihydro-5-methyl-isoquinolinone

3,4-Dihydro-5-methyl-Isoquinolinone is a small molecule experimental compound belonging to the isoquinolone class. Structurally it is a heterocyclic compound with a benzene ring fused to a pyridone ring and a methyl group at the fifth position[1][2][3]. It acts as an inhibitor of poly [ADP-ribose] polymerase 1 (PARP1), an enzyme involved in DNA repair processes. The compound has demonstrated inhibitory activity against PARP1 with reported IC50 and Ki values of approximately 150 nM and 70 nM respectively[1]. There are no approved indications or clinical trials for this agent; it remains an experimental research tool.

Other names

3,4-Dihydro-5-Methyl-Isoquinolinone3,4-dihydro-5-methylisoquinolinone1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-5-methyl-3,4-dihydroisoquinolin-1(2H)-oneCHEBI:41928CHEMBL125200CHEMBL-125200CHEMBL 125200AC1L3WIOAC-1L3WIOAC 1L3WIO