3-acetylcoumarin 6d

3-Acetylcoumarin 6d (compound 6d) is a research-stage small molecule inhibitor of human monoamine oxidase B (hMAO-B). Chemically, it is a 3-acetylcoumarin derivative featuring dichloro substituents at the Carbon-7 and Carbon-8 positions of the coumarin ring. In academic studies, the compound demonstrated potent and reversible inhibition of hMAO-B with an IC50 of 0.31 ± 0.04 μM and a selectivity index of 3.10 over MAO-A. It has shown neuroprotective effects against oxidative stress in human neuroblastoma (N2a) cells and lacks cytotoxicity against breast cancer cell lines (MDA-MB-231 and MCF-7). It is being investigated as a potential scaffold for the treatment of neurodegenerative or neuropsychiatric disorders.

Other names

7,8-dichloro-3-acetylcoumarin3-acetyl-7,8-dichlorocoumarin