3-acetylpyridine adenine dinucleotide

**3-Acetylpyridine adenine dinucleotide (APAD)** is a synthetic analogue of nicotinamide adenine dinucleotide (NAD). It consists of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by a pyrophosphate linkage, with the nicotinamide moiety replaced by a 3-acetylpyridine group. Like NAD, it acts as an electron carrier in enzymatic redox reactions and can be alternately oxidized and reduced. APAD is widely used as an experimental coenzyme in biochemical research, particularly for studying dehydrogenase enzyme mechanisms and kinetics. It serves as a substrate or inhibitor for various dehydrogenases, including those involved in bacterial and mammalian metabolism[1][2][5][7]. Its altered structure compared to NAD affects its binding properties and suitability as a substrate for certain enzymes[7].

Other names

3-acetyl-NADbeta-3-acetylpyridine adenine dinucleotidebeta3-acetylpyridine adenine dinucleotidebeta 3-acetylpyridine adenine dinucleotideMFCD00078882MFCD-00078882MFCD 00078882CHEBI:166857HY-131485AHY131485AHY 131485ANA30683NA-30683NA 30683