3-aminobenzamide

**3-aminobenzamide** is a small molecule inhibitor of the enzyme poly(ADP-ribose) polymerase (PARP), a key regulator of DNA repair, transcription control, and programmed cell death. By mimicking the structure of NAD+, 3-aminobenzamide competitively binds to the catalytic domain of PARP, inhibiting its activity, thereby preventing DNA repair and leading to NAD+ and ATP depletion in cells with activated PARP, which can result in cell death. This mechanism underlies its use as a tool compound in research on DNA damage response, radiosensitization, neuroprotection, and oxidative stress injury, and it has been investigated for potential anticancer and organ-protective applications[1][2][3][5][6].

Other names

m-aminobenzamidemeta-aminobenzamidebenzamide, 3-amino-3-amino benzamide3-aminobenzoic acid amide3-carboxamidoaniline3-aminobenzamindeaniline-3-carboxamideaniline3-carboxamideaniline 3-carboxamide3-aminobenzimide3-(aminocarbonyl)aniline