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3-aminobenzoic acid
- Development stage
- Preclinical
- Lead developer
- Osel
- Modality
- Small Molecules
- Administration
- Rectal
01
Overview
3-aminobenzoic acid (3-ABA) is a microbiome-derived metabolite and a structural isomer of aminobenzoic acid that functions as a gut barrier-protecting agent. It has been shown to decrease intestinal epithelial cell (IEC) permeability and increase trans-epithelial electrical resistance (TEER) in vitro. Research suggests that dysbiosis in patients with inflammatory bowel disease (IBD) leads to accelerated degradation of 3-ABA, resulting in significantly lower fecal levels compared to healthy individuals. In preclinical models of dextran sodium sulfate (DSS)-induced colitis, rectal administration of 3-ABA improved clinical symptoms, reduced histological damage, and suppressed the expression of pro-inflammatory cytokines. It is being explored as a potential therapeutic for restoring intestinal barrier function in IBD.
- Other names
- m-aminobenzoic acidmeta-aminobenzoic acid
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