3-deazaadenosine

3-Deazaadenosine is a synthetic small molecule and an analog of adenosine that acts primarily as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAHH), thereby regulating cellular methyltransferase activity and acting as a general methylation inhibitor[2][4][8]. By blocking SAHH, it depletes S-adenosylmethionine, the principal cellular methyl donor. This leads to broad effects on epigenetic regulation and gene expression. Mechanistically, it also directly inhibits MEK1/2 and IKKα/β kinases, suppressing AP-1 and NF-kB signaling pathways[4]. Functionally, 3-Deazaadenosine exhibits anti-inflammatory, antiproliferative (notably against vascular smooth muscle cells), antitumor (especially in leukemia cell lines), antiviral (including anti-HIV activity), antibacterial properties, and can alleviate cellular senescence[2][4][5][7][8]. It has been shown to inhibit leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation; reduce cytokines such as TNF-alpha and ILs; block histamine release by basophils; inhibit superoxide generation; prevent tumor necrosis factor-induced macrophage adhesion to endothelial cells via ICAM1 inhibition; promote monocyte apoptosis; interfere with Ras methylation/function; prevent VSMC proliferation/neointima formation in vivo[5][8].

Other names

Adenosine, 3-deaza-DZAc3Adoc-3Adoc 3Ado