Drug intelligence / Profile preview

3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide

Development stage
Unknown
Lead developer
Astex Pharmaceuticals
Modality
Small Molecules
01

Overview

**3-fluoro-N‑1H‑indol‑5‑yl‑5‑morpholin‑4‑ylbenzamide** is a synthetic small molecule belonging to the phenylmorpholine class, characterized by an indole and morpholine moiety attached to a fluorinated benzamide core. It has been identified as an inhibitor of mitogen‐activated protein kinase 14 (MAPK14, also known as p38α MAP kinase), though with relatively low potency (IC₅₀ ≈162 μM). There are no approved indications or clinical trials for this compound; it is primarily used in research settings as a chemical probe or fragment for studying MAPK14 inhibition[1][6][4]. No evidence exists of its development by any pharmaceutical company for therapeutic use.

Other names
3-Fluor-N-(1H-indol-5-yl)-5-(4-morpholinyl)benzamid3-Fluoro-N-(1H-ind–5–yl)-5-(morpholin–4–yl)benzamideBenzamide, 3-fluoro-N–1H-indol–5–yl–5-(4-morpholinyl)-
02

Targets

MAPK14 (p38 mitogen-activated protein kinase alpha)

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