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3-Phosphono-D-alanine

Development stage: Preclinical
Modality: Small Molecules

Overview

3-Phosphono-D-alanine is a synthetic amino acid derivative that functions as an excitatory amino acid antagonist. Its structural similarity to D-alanine allows it to interfere with bacterial cell wall biosynthesis by inhibiting D-alanine:D-alanine ligase (DDL), an enzyme essential for forming the D-alanyl-D-alanine dipeptide precursor. This mechanism suggests its potential as an antibacterial agent. The compound has been explored in research settings for its biochemical properties and potential therapeutic applications.

Other names: D-2-Amino-3-Phosphono-Propionic AcidD2-Amino-3-Phosphono-Propionic AcidD 2-Amino-3-Phosphono-Propionic Acid3-phosphonoalaninePhosphonoalanine

Targets

DdlA (D-alanyl-D-alanine Synthetase)NMDAR (Glutamate receptor ionotropic, NMDA)

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