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3-PLG-A-GSH
- Development stage
- Preclinical
- Lead developer
- Biological Research Centre, Szeged
- Modality
- Nanoparticles → Drug Delivery Systems, Peptides
- Administration
- Intravenous
01
Overview
3-PLG-A-GSH is an experimental 3-armed poly(L-glutamic acid) (PLG) polypeptide nanocarrier dual-functionalized with alanine (A) and glutathione (GSH) ligands. It is designed to enhance drug delivery across the blood-brain barrier (BBB) by targeting nutrient transporters on cerebral endothelial cells. The combination of alanine and glutathione ligands facilitates active, time-dependent cellular uptake and increased permeability through the BBB. Research has demonstrated its ability to enter midbrain-like organoids, including those derived from Parkinson's disease patient-specific stem cells, suggesting potential applications in treating central nervous system disorders.
- Other names
- 3-armed poly(L-glutamic acid) alanine-glutathione nanoparticlealanine and glutathione dual-targeted 3-armed poly(L-glutamic acid) nanoparticle
02
Targets
SLC7A5 (Large neutral amino acid transporter small subunit 1)GSH-T (Sodium-dependent glutathione transporter)
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