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30% ethanolic propolis extract
- Development stage
- Unknown
- Lead developer
- Dow University of Health Sciences
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
30% ethanolic propolis extract is a botanical formulation derived from a natural resinous substance collected by honeybees (*Apis mellifera*) from plant exudates, specifically *Acacia modesta* in the Margalla Hills. Investigated by the Dow University of Health Sciences for the treatment of dentin hypersensitivity, the extract contains bioactive compounds such as bioflavonoids. It works through a dual mechanism: physically occluding exposed dentin tubules by forming crystals and biologically stimulating the production of transforming growth factor-beta 1 (TGF-β1), which induces the differentiation of odontoblast-like cells to promote reparative dentin formation.
- Other names
- ethanolic extract of propolisEEPpropolis extract
02
Targets
TGFB1 (Transforming growth factor Beta-1 proprotein)
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