30% glucose solution

30% glucose solution is a concentrated carbohydrate solution utilized as a non-pharmacological analgesic intervention for procedural pain in neonates. In a clinical trial conducted by Region Örebro County at Örebro University Hospital, the solution was evaluated for its efficacy in reducing pain during routine neonatal hip examinations. The mechanism of action involves the stimulation of sweet taste receptors (TAS1R2 and TAS1R3) on the tongue, which activates the endogenous opioid system, leading to a reduction in crying time and pain scores. It is typically administered orally in small volumes (e.g., 2 ml) shortly before a painful procedure. This intervention is widely used in neonatal care as a safe and effective method for managing minor procedural distress.

Other names

glucosedextroseoral sweet solutionoral glucose