Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
30% metformin gel
- Development stage
- Unknown
- Lead developer
- Jinnah Postgraduate Medical Centre
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
30% metformin gel is a topical formulation of the biguanide metformin being investigated for the treatment of melasma. While metformin is primarily known as an oral antihyperglycemic agent for type 2 diabetes, its topical application targets hyperpigmentation through the activation of AMP-activated protein kinase (AMPK). This activation leads to the downregulation of melanogenesis-related genes and enzymes, such as tyrosinase and microphthalmia-associated transcription factor (MITF), effectively reducing melanin synthesis. The Jinnah Postgraduate Medical Centre is evaluating this 30% concentration in clinical trials to compare its efficacy and safety against the gold-standard triple combination cream containing hydroquinone, tretinoin, and fluocinolone acetonide.
- Other names
- metformin geltopical metformin
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)
Beyond the preview
Go deeper on 30% metformin gel.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 30% metformin gel.