Drug intelligence / Profile preview

3Mix-MP Antibiotic Paste

Development stage
Phase 3
Lead developer
Uşak University
Modality
Small Molecules
Administration
Topical
01

Overview

3Mix-MP Antibiotic Paste is a locally applied antibacterial dental paste used in Lesion Sterilization and Tissue Repair (LSTR) therapy, a non-instrumentation endodontic approach for treating infected primary teeth. It consists of a triple antibiotic mixture ('3Mix') — metronidazole, ciprofloxacin, and minocycline — combined with a vehicle of macrogol (polyethylene glycol) and propylene glycol ('MP'), which facilitates diffusion of the antibiotics through dentinal tubules to disinfect infected root canal systems and periapical lesions. The paste is placed at root canal orifices or on the floor of the pulp chamber without radicular instrumentation, then sealed with restorative materials. It is used to treat pulp necrosis and irreversible pulpitis, primarily in primary (deciduous) teeth in pediatric patients.

Other names
3Mix-MP3Mix-MP pasteLSTR 3Mix-MPLSTR3Mix-MPLSTR-3Mix-MPLSTR 3Mix-MP pasteLSTR3Mix-MP pasteLSTR-3Mix-MP pasteTAPtriple antibiotic paste
02

Targets

Bacterial RibosomeNeuraminidaseDNA gyraseTopo IV (Bacterial Topoisomerase IV)DNA

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