3TSR

3TSR is a recombinant protein fragment derived from the anti-angiogenic domain of Thrombospondin-1 (TSP1), specifically consisting of the three type 1 thrombospondin structural repeats. It functions as a potent inhibitor of angiogenesis by interacting with receptors such as CD36 on endothelial cells, which triggers signaling pathways that induce apoptosis and inhibit endothelial cell migration. Unlike full-length TSP1, which requires proteolytic cleavage by enzymes like ADAMTS1 to release its active anti-angiogenic fragments, 3TSR is a pre-activated form that bypasses this regulatory step. Preclinical research has demonstrated that 3TSR can effectively inhibit tumor growth and metastasis in various cancer models, including melanoma, colon carcinoma, and renal cell carcinoma, particularly in organ sites like the liver and lungs where endogenous TSP1 activation may be limited.

Other names

Thrombospondin-1 Type 1 RepeatsThrombospondin1 Type 1 RepeatsThrombospondin 1 Type 1 RepeatsTSP-1 3TSRTSP1 3TSRTSP 1 3TSR3TSR domain