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4-(fluorophenyl)-1-cyclopropylmethyl-5-(2-amino-4-pyrimidinyl)imidazole
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
4-(Fluorophenyl)-1-cyclopropylmethyl-5-(2-amino-4-pyrimidinyl)imidazole is a synthetic small molecule belonging to the phenylimidazole class of organic compounds. It has a molecular formula of C17H16FN5 and a monoisotopic mass of approximately 309.14 Da[2][1]. The compound is primarily characterized as an experimental agent, with no approved therapeutic indications or brand names currently available. Its most notable biological activity is potent inhibition of mitogen‑activated protein kinase 14 (MAPK14, also known as p38α MAP kinase), with an IC50 value reported at approximately 25 nM[2]. This suggests potential utility in modulating inflammatory or stress response pathways where MAPK14 plays a central role.
- Other names
- 4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amineUNII R37TCQ1HFT
02
Targets
MAPK14 (p38 mitogen-activated protein kinase alpha)
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