4-Borono-2-18F-fluoro-L-phenylalanine-fructose

4-Borono-2-(\^{18})F-fluoro-L-phenylalanine-fructose (commonly referred to as 18F-BPA-Fr or 18F-FBPA) is a radiolabeled amino acid analog used primarily as a positron emission tomography (PET) imaging agent. It is an analog of boronophenylalanine (BPA), which is used in boron neutron capture therapy (BNCT), an experimental form of radiotherapy for cancers such as glioblastoma multiforme and melanoma. The primary purpose of administering 18F-BPA-Fr is to noninvasively assess the biodistribution and tumor uptake of BPA prior to BNCT, enabling patient selection and treatment planning. Mechanistically, it enters tumor cells mainly via L-type amino acid transporters, reflecting the pharmacokinetics and tissue distribution expected from therapeutic BPA administration[1][2][3][5]. The compound is metabolically stable, with its tumoral accumulation correlating with DNA synthesis activity[1]. PET imaging with this tracer allows estimation of boron concentration in tumors before BNCT[3][7].

Other names

fluorine-18-BPA-fructosefluorine18-BPA-fructosefluorine 18-BPA-fructose[18F]fluoro-boronophenylalanine-fructose