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Drug intelligence / Profile preview
4-iodo-acetamido phenylboronic acid
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
4-Iodo-acetamido phenylboronic acid is a synthetic small molecule boronic acid derivative with the molecular formula C8H9BINO3 and a molecular weight of approximately 304.88 g/mol[1][5][7]. It acts as a transition-state analogue inhibitor of class C beta-lactamases, covalently binding to the active-site serine residue (Ser64), thereby inhibiting the enzyme's activity[10]. This compound has been studied primarily in structural biology and enzymology research as an experimental tool to investigate mechanisms of beta-lactamase inhibition and antibiotic resistance[10]. It is not approved for clinical use or marketed as a pharmaceutical drug.
- Other names
- 4-IODO-ACETAMIDO PHENYLBORONIC ACID(3-(2-Iodoacetamido)phenyl)boronic acidAcide {3-[(2-iodoacétyl)amino]phényl}boroniqueBoronic acid, B-[3-[(2-iodoacetyl)amino]phenyl]{3-[(Iodacetyl)amino]phenyl}borsäure
02
Targets
AmpC (AmpC beta-lactamase)
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