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4-methoxy-17-picolinyliden-androst-4-en-3-one
- Development stage
- Preclinical
- Lead developer
- University of Novi Sad
- Modality
- Small Molecules
01
Overview
4-methoxy-17-picolinyliden-androst-4-en-3-one is a synthetic heterocyclic steroid derivative belonging to the class of 17-picolinylidene androstanes. It is being investigated as a potential antineoplastic agent, specifically targeting aggressive and treatment-resistant cancers such as triple-negative breast cancer (TNBC) and prostate cancer. The compound's mechanism of action involves the induction of apoptotic cell death and the modulation of the cell cycle, which allows it to bypass defective apoptotic pathways often found in malignant cells. Developed within academic research frameworks, this steroidal compound aims to provide high antiproliferative activity with improved selectivity and lower systemic toxicity compared to conventional chemotherapy.
- Other names
- 4-methoxy-17-(2-pyridylmethylene)androst-4-en-3-one17(E)-picolinylidene-4-methoxyandrost-4-en-3-one
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